Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis
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منابع مشابه
Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis.
Fracture healing and distraction osteogenesis have important applications in orthopedic, maxillofacial, and periodontal treatment. In this review, the cellular and molecular mechanisms that regulate fracture repair are contrasted with bone regeneration that occurs during distraction osteogenesis. While both processes have many common features, unique differences are observed in the temporal app...
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The process of fracture healing has been described in detail in many histological studies. Recent work has focused on the mechanisms by which growth and differentiation factors regulate the fracture healing process. Rapid progress in skeletal cellular and molecular biology has led to the identification of many signaling molecules associated with the formation of skeletal tissues, including memb...
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COPYRIGHT © 2015 BY THE JOURNAL OF BONE AND JOINT SURGERY, INCORPORATED » Distraction osteogenesis, utilized for reconstruction of skeletal deformities and bone defects, encompasses three phases of repair that are distinct from those of fracture-healing: latency, distraction, and consolidation. During distraction, osteogenic potential is maintained because of a number of molecular, cellular, an...
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Low-intensity ultrasound is a biophysical form of intervention in the fracture-repair process, which through several mechanisms accelerates healing of fresh fractures and enhances callus formation in delayed unions and nonunions. The goal of this review is to present the current knowledge obtained from basic science and animal studies, as well as existing evidence from clinical trials and case ...
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Distraction osteogenesis biologically resembles fracture healing with distinctive characteristics notably in the distraction phase of osteogenesis. In the latency phase of bone lengthening, like in the inflammatory phase of fracture repair, interleukines are released and act with growth factors released from platelets in the local haematoma, leading to attraction, proliferation and differentiat...
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